B.S. Montana State University, Bozeman, 1982, Microbiology
M.S. Washington State University, Pullman, 1984, Microbiology
Ph.D. Washington State University, Pullman, 1986, Immunology/Vet Science
Postdoctoral Stanford University, Stanford, California, 1989, Immunology

Honors

Editorial Board, Transplantation (1992-2002).

Associate Editor, J. Immunology (1994-1999).

Section Editor, J. Immunology (2001-presnt)

 Charles and Nora Wiley Award for meritorious research. Montana State University, 1993.

Alberta Heritage Foundation Visiting Scientist, Calgary, 1994.

MSU Alumni Association/Chamber of Commerce Award for Excellence, 1999.

American Heart Association Council, Northwest Affiliate (2001-present).

Cox Award for Creative Scholarship and Teaching, Montana State University, 2001.

Patents
Antibodies with specificities for multiple adhesion molecules. PCT/US93/04999, U.S. Serial No. 07/887,695, patent awarded.

      2. Jutila, M.A., and  McIvor, K.L.  1986.  Release of a chemotactic monokine upon treatment with lymphocyte supernatants.   J. Leuk. Biol.  39:533.

      3. Jutila, M.A., and Banks, K.L.  1986.  Locally dividing macrophages of normal and inflamed mammary glands.  Clin. Exp. Immunol.  66:615.

      4. Jutila, M.A., and Banks, K.L. 1988.  Increased synovial fluid macrophage division in Caprine Arthritis-Encephalitis virus infection.  J. Infect. Disease  157:1193.

      5. Banks, K.L., Jutila, M.A., Jacobs, C.A., and Michaels, F.H. 1989. Augmentation of lymphocyte and macrophage proliferation by Caprine Arthritis-Enchephalitis virus contributes to the development of progressive arthritis. Rheum. Internat. 9: 123-128.

      6. Jutila, M.A., Kroese, F.G.M., Jutila, K.L., Stall, A., Friering, S, Lakey Berg, E., Herzenberg, L.A., and Butcher, E.C. 1989. Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. Eur. J. Immunol.  18:1819.

      7. Lakey Berg, E., Goldstein, L., Jutila, M.A., Nakache, M., Picker, L.J., Streeter, P.R., Zhou, D., Wu, N., and Butcher, E.C. 1989. Homing receptors and vascular addressins: Cell adhesion molecules that direct lymphocyte traffic. Immunol. Rev.  108:5.

      8. Bishop, D.K., Jutila, M.A., Sedmak, D.D., Beattie, M.S., and Orosz, C.G. 1989. Lymphocyte entry into inflammatory tissues in vivo: Qualitative differences of high endothelial venule-like vessels in sponge matrix allografts vs. isografts. J. Immunol. 142: 4219-4224.

      9. Jutila, M.A., Berg, E.L., Kishimoto, T.K., Picker, L.J., Bargatze, R F., Bishop, D.K., Orosz, C.G., Wu, N.W., and Butcher, E.C. 1989. Inflammation induced endothelial cell adhesion to lymphocytes, neutrophils and monocytes: Role of homing receptors and other adhesion molecules. Transplantation,  48: 727-731.

      10 . Jutila, M.A., Rott, L., Lakey Berg, E., and Butcher, E.C. 1989.  In vivo regulation and function of the MEL-14 defined antigen on murine neutrophils: Comparison with Mac-1 and LFA-1. J. Immunol.  143:3318-3324.

      11. Kishimoto, T.K., Jutila, M.A., Berg, E.L., and Butcher, E.C. 1989. The Mac-1 and Mel-14 defined adhesion molecules are diametrically regulated on neutrophils by chemotactic factors. Science  245:1238-1241.

      12. Webster, E.L., Tracey, D.E., Jutila, M.A., Wolf Jr., S.A., and De Souza, E.B. 1990. Corticotropin-releasing factor (CRF) receptors in mouse spleen: Identification of receptor-bearing cells as resident macrophages. Endocrinol.  127:440-452.

      13. Kishimoto, T.K., Jutila, M.A., and Butcher, E.C. 1990. Identification of a human peripheral lymph node homing receptor: A rapidly down-regulated adhesion molecule. Proc. Natl. Acad. Sci.   87:2244-2248.

      14. Jutila, M.A., Kishimoto, T.K., and Butcher, E.C. 1990. Regulation and lectin activity of the human neutrophil peripheral lymph node homing receptor. Blood 176: 178-183.

      15. Cutler, J.E., Brawner, D.L., Hazen, K.C., and Jutila, M.A. 1990. Characteristics of Candida albicans adherence to mouse tissues.  Infect. & Immun. 58:1902-1908.

      16. Jutila, M.A., Kishimoto, T.K., and Finken, M. 1991. Low dose chymotrypsin treatment inhibits neutrophil migration into sites of inflammation in vivo: Effects on Mac-1 and MEL-14 adhesion protein expression and function. Cell. Immunol. 132: 201-214.

      17. Hallmann, R., Jutila, M.A., Smith, C.W., Anderson, D.C., Kishimoto, T.K., and Butcher, E.C.  1991. The peripheral lymph node homing receptor, LECAM-1, in involved in CD18-independent adhesion of human neutrophils to endothelium. Biochem. Biophys. Res. Comm.  174:236-243.

      18. Hazen, K.C., Brawner, D.L., Jutila, M.A., and Cutler, J.E. 1991. Differential adhesionrence between hydrophobic and hydrophilic yeast cells of Candida albicans to mouse tissues. Infect. & Immun.  59:907.

      19. Kishimoto, T.K., Warnock, R.A., Jutila, M.A., Butcher, E.C., Anderson, D.C., and Smith, C.W. 1991. Antibodies against human neutrophil LECAM-1 (DREG56/LAM-1/Leu-8 antigen) and endothelial cell ELAM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78:805-811.

      20. Walcheck, B., White, M., Kurk, S., and Jutila, M.A. 1992. Characterization of the bovine peripheral lymph node homing receptor: A lectin cell adhesion molecule (LECAM). Eur. J. Immunol. 22: 469-476.

      21. Palecanda, A., Walcheck, B., Bishop, D.K., and Jutila, M.A. 1992. Rapid activation independent shedding of LECAM-1 induced by cross-linking agents. Eur. J. Immunol.  22: 1279-1286.

      22. Kanbe, T., Jutila, M.A., and Cutler, J.E. 1992. Evidence that Candida albicans binds to a unique adhesion system on phagocytic cells in the marginal zone of mouse spleen. Infect. & Immun.   60: 1972-1978.

      23. Jutila, M.A. 1992. Leukocyte traffic to sites of inflammation. Act. Path. Micro. Immun. Scan.  100:191.

      24. Jutila, M.A., Watts, G., Walcheck, B. and Kansas, G. 1992. Characterization of a functionally important and evolutionarily conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin. J. Exp. Med.  175: 1565-1573.

      25.  Jutila, C.K., Jutila, M.A., Crowell, R.E., Chick,T.W., Van Epps, D.E., and Reed, W.P.  1992.  Neutrophil responses to intravascular pneumococcal sonicate.  Inflammation, 16: 135-146.

      26. Walcheck, B., and Jutila, M.A.  1993.  Bovine gamma/delta T-cells express high levels of functional peripheral lymph node homing receptor (L-selectin).  Intl. Immunol., 6, 81-91.

      27.  Jutila, M.A., Berg, E.L., Kroese, G.M, Rott, L., Perry, V., and Butcher, E.C.  1993.  In vivo distribution and characterization of two novel mononuclear phagocyte differentiation antigens in the mouse.  J. Leuk. Biol. 54: 30-39.

      28. Walcheck, B., Watts, G., and Jutila, M.A. 1993. Gamma/delta T cells bind E-selectin via a novel glycoprotein receptor: Characterization of the first lymphocyte–E-selectin interaction in an animal model. J. Exp. Med. 178: 853-863.

      29.  Jutila, M.A.  1994.  Selectins in leukocyte extravasation:  function of a common epitope on L- and E-selectin.  Advances in Pharmacology  25: 235-256..

      30. Jutila, D.B., Kurk, S., and Jutila, M.A.  1994.  Differences in the expression of Ly-6C on neutrophils and monocytes following PI-PLC hydrolysis and cellular activation. Immunol. Letters, 41:49-57.

      31. Abrahamsen, M., Tintzman, R., Jutila, M.A., Speer, C.A., and White, M. 1994. Eimeria bovis: Expression of a related group of refractile body-associated proteins during schizogy.  Exp. Parasitology  78: 331-335.

      32. Jutila, M.A. 1994. Function and regulation of leukocyte homing receptors.  J. Leuk. Biol.,  55, 133-140..

      33. Steinberg, J.B., Mao, H-Z, Niles, S.D., Jutila, M.A., and Kapelanski, D.P. 1994. Survival in lung reperfusion injury is improved by an antibody that binds and inhibits L- and E-selectin. J. Heart and Lung Transplant     13: 306-318.

      34.  Bargatze, R., Kurk, S., Watts, G., Kishimoto, T.K., Speer, C.A., and Jutila, M.A.  1994.  In vivo and in vitro functional examination of conserved epitope of L- and E-selectin crucial for leukocyte-endothelial cell interactions.  J. Immunol. 152: 5814-5825.

      35. Bargatze, R.F., Kurk, S., Butcher, E.C., and Jutila, M.A. 1994. Neutrophils roll on adherent neutrophils bound to cytokine-stimulated endothelium via L-selectin on the rolling cells.  J. Exp. Med.,  180: 1785-1792.

      36. Qian, Q., Jutila, M.A., Van Rooijen, N., and Cutler, J.E. 1994. Elimination of mouse splenic macrophages correlates with increased susceptibility to experimental disseminated candidiasis. J. Immunol., 152: 5000-5008.

      37. Jutila, M.A., Bargatze, R.F., Kurk, S., Warnock, R.A., Ehsani, N., Watson, S., and Walcheck, B. 1994. Cell surface P- and E-selectin support shear-dependent rolling of bovine g/d T cells. J. Immunol.,  153: 3917-3928.

      38.  Ridings, P.C., Windsor, A.C.J., Jutila, M.A., Blocher, C., Fisher, B.J., Fowler, A.A., and Sugerman, H.J. 1994. A dual binding antibody to E-selectin and L-selectin protects against sepsis-induced lung injury.  Am. J. Res. Crit. Care. Med., 152: 247-253.

      39.  Kubes, P., Jutila, M.A., and Payne, D. 1995. Therapeutic potential of inhibiting leukocyte rolling in ischemia/reperfusion. J. Clin. Invest. , 95:2510-2519.

      40.  Bargatze, R., Jutila, M.A., and Butcher, E.C. 1995. Distinct roles for L-selectin,  a4 integrin, and LFA-1 in lymphocyte interactions with HEV in situ:: the multi-step model confirmed and refined. Immunity, 3:99-108.

      41.  Burritt, J.B., Quinn, M.T., Jutila, M.A., Bond, C.W., Jesaitis, A.J.  1995.  Topological mapping of neutrophil cytochrome B epitopes with phage-display libraries.  J. Biol. Chem., 270:16974-16980.

  42. Fowler, A.A.,III, and Sugerman, H.J.  1995. Sepsis-induced acute lung injury is attenuated by selectin blockade following the onset of sepsis. Arch.Surg. 130: 1199-1208.

      43.  Jutila, M.A. and Kurk, S.  1996.  Analysis of bovine g/d T cell interactions with E-, P-, and L-selectin:  Characterization of lymphocyte on lymphocyte rolling and the effects of O-glycoprotease.  J. Immunol., 156: 289-296.

      44.  Jones, W.M., Walcheck, B., and Jutila, M.A.  1996.  Generation of a new gd T cell-specific monoclonal antibody (GD3.5):  Biochemical comparisons of GD3.5 antigen with the previously described WC1 family.  J. Immunol., 156: 3772-3779.

45. Jutila, M.A. 1996. Gamma/delta T cell/endothelial cell interactions. Vet. Immunol. Immunopath., 54:105-110.

      46. DeLeo, F., Jutila, M.A., and Quinn, M.T. 1996. Characterization of peptide diffusion into electropermeabilized neutrophils. J. Immunol. Methods, 198: 35-49.

      47. Hickey, M.J., Reinhardt, P.H., Ostrovsky, L., Jones, W.M., Jutila, M.A., Payne, D., Elliot, J., and Kubes, P.  1997. Tumor necrosis factor-alpha induces leukocyte recruitment by different mechanisms in vivo and in vitro.  J. Immunol.,  158:3391-3400.

      48.  Seekamp, A., Regel, G., Rother, K., Griensven, M.V., and Jutila, M. 1997.  The effect of anti-L-selectin (EL-246) on remote lung injury after infrarenal ischemia/reperfusion.  Shock, 7: 447-454..

      49. McEvoy, L.M., Jutila, M.A., Tsao, P.S., Cooke, J.P., Berg, E.L., and Butcher, E.C. 1997.  Anti-CD43 inhibits monocyte-endothelial cell adhesion in inflammation and atherogenesis.  Blood, 90:3587-3594.

      50. Jutila, M.A., Wilson, E., and Kurk, S. 1997. Identification and characterization of an adhesion molecule that mediates leukocyte rolling on 24-hour cytokine stimulated bovine endothelial cells under flow conditions. J. Exp. Med.,  186:1701-1711.

      51.  Abrahamsen, M.S., Lancto, C., Walcheck, B., and Jutila, M.A. 1997. Recruitment of leukocytes to Cryptosporidium infected tissues.  Infect. Immun., 65:2428-2433.

      52.  Jones, W.  Watts, G., Robinson, M., Vestweber, D., and Jutila, M.A. 1997.  Comparison of E-selectin binding glycoprotein ligands on human lymphocytes and neutrophils, and bovine gamma/delta T cells.  J. Immunol.,  159: 3574-3583.

      54. Leid, J.G., Speer, C.A., and Jutila, M.A.  1998. Comparative ultrastructure and expression of L-selectin on bovine  a/b and g/d T cells.  J. Leuk. Biol.   64:104-107.

      55.Wilson, E., Walcheck, B., Davis, W., and Jutila, M.A. 1998.  Preferential tissue localization of bovine gamma delta T cell subsets defined by anti-T-cell receptor for antigen antibodies.  Immunol. L., 64: 39-44.,

     56. Wilson, E., Aydintug, K., and Jutila, M.A. 1999. A circulating bovine gd T cell subset, which is found in large numbers in spleen, accumulates inefficiently at sites of inflammation: correlation with lack of E-selectin ligands and L-selectin. J. Immunol., 162:4914-4919.

      57. Sipes, K., H. Edens, M. Kehrli, H. Miettinen, J. Cutler, M.A. Jutila, and M.Quinn. 1999.  Analysis of surface antigen  expression and host defense function in leukocytes from calves with bovine leukocyte adhesion  deficiency: Comparison of heterozygous and homozygous animals.  Am. J. Vet. Res., 60:1255-1261.  

     58. Csencsits, K.L., M.A. Jutila, and D.W. Pascual. 1999.  Nasal-associated lymphoid tissue (NALT): peripheral node addressin predominates in naïve lymphocyte adhesion to HEV in a mucosal site.  J. Immunol., 163: 1382-1389.

      59. Soltys, J., S.D. Swain, K.M. Sipes, L.K. Nelson, M.A. Jutila, and M.T. Quinn. 1999.  Isolation of bovine neutrophils with biomagnetic beads: Comparison with standard percoll density isolation methods.  J. Immunol. Meth. 226: 71-84.

      60. Kantele, J.M., S. Kurk, and M.A. Jutila. 2000. Effects of continuous exposure to SDF-1 on T cell rolling and tight adhesion to monolayers of activated endothelial cells. J. Immunol., 164: 5035-5040.

      61. DeMaula, C.D., Jutila, M.A., Wilson, D.W. and MacLachlan, N.J. 2001. Infection kinetics, prostacyclin release, and cytokine-mediated modulation of the mechanism of cell death during bluetongue virus infection of cultured ovine and bovine pulmonary artery and lung microvascular endothelial cells.  J. Gen. Virol. 82:787-794.                                                                

62. Carter YM, Thomas R, Bargatze R, Jutila M, Murry C, Allen MD. 2001. Intracoronary E- and L-selectin blockade attenuates myocardial neutrophil infiltration in cardiac ischemia/reperfusion injury.  Curr Surg. 57:639.

      63. Leid, J.G., Steeber, D.A., Tedder, T.F., and Jutila, M.A. 2001.  Antibody binding to a conformation-dependent epitope  induces L-selectin associate with the detergent resistant  cytoskeleton. J. Immunol., 166: 4899-4907.

      64.  Quinn, M.T., Swain S.D., Parkos C.A., Jutila K.L., Siemsen D.W., Kurk, S.L., Jesaitis A.J., and Jutila M.A. 2001.  A carbohydrate neoepitope that is up-regulated on human mononuclear leukocytes by neuraminidase treatment or cellular activation.   Immunology, 104: 185-197.

      65. Leid, J.G., Speer, C.A., and Jutila, M.A. 2002. Ultrastructural Examination of Cytoskeletal Linkage of L-selectin and Comparison of L-selectin Cytoskeletal Association to that of Other Human and Bovine Lymphocyte Surface Antigens^.   Cellular Immunology, 215:219

      66. DeMaula, C.D., Leutenegger C.M., Jutila, M.A., and MacLachlan, N.J. 2002.  Bluetongue virus-induced activation of primary bovine lung microvascular  endothelial cells.  Vet. Immunol. Immunopath.  86:147

      67. Csencsits, K.L., Jutila, M.A., and Pascual, D.W. 2002.  Mucosal addressin (MAdCAM-1) expression and naïve lymphocyte binding interactions vary among the cranial, oral, and nasal-associated lymphoid tissues (CONALT). Eur. J. Immunol., 32:3029

68.    Jutila, M.A., Kurk S., Jackiw L., Knibbs R.N., and Stoolman, L.M. 2002. L-selectin can serve as an E-selectin ligand on human T-cell blasts. J. Immunol., 169:1768

69.   Wilson E.,Hedges J. F.,Butcher E.C., Briskin M., and Jutila, M.A. 2002. Bovine gd T cells subsets express distinct patterns o f nd chemokine responsiveness adhesion molecules:  A Mechanism for for tissue specific gd T cell subset accumulation.   J. Immunol., 169:4970.

70.    Meissner N., Radke J.,Hedges J. F.,White M., Behnke M., Bertolino S., Abrahamsen# M. Hedges, and Jutila, M.A. 2003. ative Serial analysis of gene expression (SAGE) in circulating CD8+ and CD8- gd T cells. J. Immunol., 170:356 

71.    Hedges, J.F.,  Cockrell, D.,Jackiw, L. Meissner, N., , and Jutila, M.A. 2003. Differential mRNA expression in circulating gamma delta T lymphocyte subsets defines unique tissue-specific functions. J. Leuk. Biol., 73:306

72. Leid, J. and Jutila, M.A. 2004. Impact of Polyunsaturated Fatty Acids on Cytoskeletal linkage of L-selectin. Cellular Immunol, 228: 91-98.

73. Hedges, J.F., Lubick, K., and Jutila, M.A. 2004. gd T cells respond directly to pathogen associated molecular patterns. J.Immunol. (pending acceptance of revisions).

74. Graff, J.C., Behnke, M., Radke, J., White, M., Lee, D., and Jutila, M.A. 2005. A comprehensive SAGE database for the analysis of gd T cells. To be submitted.

75. Lubick, K. and Jutila, M.A. 2005. gd T cells express CD36. In preparation.

76. Lancto, C.A., Walcheck, B., Jutila, M.A., and Abrahamsen, M.S. 2005 Role of PNAd in lymphocyte recruitment during Cryptosporidium parvum infection. Submitted.

Inflammatory disease and developmental immunology. My laboratory studies the molecular events that control leukocyte entry into sites of acute and chronic inflammation. Analyses of gamma/delta T cells are also pursued in the context of host immune responses and developmental immunology.

Grants and Awards:

Principal Investigator. (total>$16,500,000 since 1990)

Co-Principal Investigator (total>$12,000,000, since 1990).

Graduate Students: