Research in
the White laboratory focuses on the Apicomplexan protozoans
which are responsible for a significant burden of infectious
disease in the world. Malarial
parasites are the most infamous members of this phylum as
they are responsible for enormous human suffering and
mortality---killing annually more than a million children in
Africa alone. Five
hundred million individuals are estimated by WHO to suffer
from malaria world-wide.
The coccidian members of the Apicomplexa such as Toxoplasma
and Cryptosporidium cause opportunistic infections in
humans particularly immunocompromised individuals such as
those infected with the HIV virus.
The lay-person may know Toxoplasma from
cautions given pregnant women to avoid contact with the
cat box because infections with this parasite can cause birth
defects or miscarriages.
Other coccidians including the Eimeria, Neospora,
and Isopora, are important in veterinary medicine,
causing serious systemic, enteric, and respiratory disease in
livestock.